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Scientists Just Warned About a Common Vitamin D Supplement Mistake | Dr. Mandell

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Most people think vitamin D is just vitamin D, but a new scientific analysis suggests there may be a common supplement mistake millions are making without realizing it. In this video, Dr. Mandell explains the important differences between vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), why your body may respond differently to each form, how vitamin D functions more like a hormone than a traditional vitamin, and why absorption, dosage, magnesium status, and proper supplementation matter. Before you take your next vitamin D capsule, check your bottle. This simple step could change how you support your bones, muscles, immune system, and overall health.

PUBMED REFERENCES
Brown EIG, Frost GS, Smith CP, et al. Effect of vitamin D2 supplementation on 25-hydroxyvitamin D3 status: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews. 2025. PMID: 40973107

Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. American Journal of Clinical Nutrition. 2012, 95(6):1357-1364. PMID: 22552031

Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. Journal of Clinical Endocrinology and Metabolism. 2004, 89(11):5387-5391. PMID: 15531486

Optional fourth if you want stronger immune angle:

Tripkovic L, Wilson LR, Hart K, et al. Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women. American Journal of Clinical Nutrition. 2017, 106(2):481-490. PMID: 28679555

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Please share this video with your friends and family. Wishing you and your family many Blessings! ❤️???????? Dr M

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Category
Medical
Tags
vitamin d, vitamin d3, vitamin d2
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